Celecoxib (Celebrex) Drug for Pain: Use, Side Effects, Interactions

Celecoxib
(Celebrex, United States)

Use:

Celecoxib or Celebrex is used to reduce pain and inflammation.

How It Works:

Celecoxib or Celebrex is a COX-2 specific inhibitor. Cyclo oxygenase compounds are found throughout the body - for example, in the nervous system and stomach. COX-2 is a type of cyclo oxygenase that produces prostaglandins that cause pain and inflammation. COX-1 is a type of cyclo oxygenase that is found in the stomach that helps protect the stomach lining. Thus, being specific for COX-2, Celecoxib or Celebrex reduces pain and inflammation with little stomach irritation.

Side Effects:

Celecoxib or Celebrex is generally well tolerated. It has a lower incidence of stomach side effects - irritation, ulcers, and even bleeding - than other anti inflammatory drugs.

Cautions for People:

People who have a sensitivity to other anti inflammatory drugs may be able to tolerate Celecoxib or Celebrex, however they should use it with caution.

Drug Interactions:

While Celecoxib or Celebrex does have a lower incidence of stomach adverse effects, care must be taken when combining it with other drugs, most notably other anti inflammatory drugs, because stomach irritation may result.

Further Reading:

Am J Med 1998;104(5):413

Added to Virtual Drugstore August 1998.

The relevant product monographs must be regarded as the appropriate sources of prescribing information.