Valsartan or Diovan is used for blood pressure control.
In the body the angiotensin-renin system is involved in blood pressure control. Valsartan or Diovan blocks one part of this system - angiotensin II - at its receptor sites. Angiotensin II, thus, is unable to act - blood vessel constriction and salt and water retention does not occur.
Allergy, stomach irritation, dizziness, too low a blood pressure, and alterations in taste have been reported, however their occurrence is not common. One side effect that is problematic with other types of drugs that affect the angiotensin-renin system is a cough. Valsartan or Diovan does not seem to be associated with a cough.
Because Valsartan or Diovan affects the angiotensin-renin system and this system is intimately linked to kidney function, people with kidney problems should be evaluated thoroughly before they take Valsartan or Diovan.
Valsartan or Diovan is commonly used in combination with other cardiovascular drug. Care must be taken if a potassium supplement is given along with Valsartan or Diovan - too high potassium levels may occur.
Clin Pharmacol Ther 1996;60:341
Clin Pharmacol Ther 1996;61:35
Medical Letter 1997;39:43
The relevant product monographs must be regarded as the appropriate sources of prescribing information.