Losartan or Cozaar is an antihypertensive drug which lowers blood pressure.
Losartan or Cozaar acts on the angiotensin part of your body's renin system in the body. A specific type of angiotensin, angiotensin II, acts to increase the body's fluid volume and thus to increase the blood pressure. Losartan or Cozaar blocks this angiotensin's action and consequently reduces blood pressure.
Losartan or Cozaar is closely related to the angiotensin converting enzyme (ACE) inhibitors in that the net result of both is inactivation of angiotensin.
Losartan or Cozaar is well tolerated. Too low a blood pressure has been reported - fainting, dizziness, lightheadedness especially when standing or sitting up quickly - but an adjustment in dose may resolve this problem. Gastrointestinal, that is stomach, symptoms are sometimes seen, for example diarrhea, indigestion, nausea.
Cough can be a major problem with ACE inhibitors and can even mean stopping the drug. Losartan or Cozaar, because it works in a different manner to obtain the same effect on the renin system, has a significantly lower incident of cough and can be considered an alternative to ACE inhibitors.
Pregnant individuals and those who have too low a blood pressure, that is are hypotensive, should not take Losartan or Cozaar. People with certain conditions such as impaired liver function and valvular stenosis should be careful when they take Losartan or Cozaar because the drug can complicate their condition. Nursing mothers should also be careful because Losartan or Cozaar does have the potential to appear in the milk.
Because Losartan or Cozaar lowers blood pressure, any other drugs that also lower blood pressure should be used with actions care in combination, because too low a blood pressure may result.
Arch Intern Med 1995;155:405
Med Letter 1995;37:57
The relevant product monographs must be regarded as the appropriate sources of prescribing information.