Irbesartan or Avapro is indicated for high blood pressure or hypertension.
Irbesartan or Avapro is a angiotensin II receptor antagonist which blocks the binding of angiotensin II to type 1 angiotensin II receptors, which means that angiotensin can not elicit its vasoconstriction actions. Blood pressure is lowered.
Irbesartan or Avapro is well tolerated. Cough is a side effect associated with ACE inhibitors, but by affecting the angiotensin system in the way it does, Irbesartan or Avapro avoids this cough side effect.
Irbesartan or Avapro should not be used in pregnant women because it is toxic to the developing fetus.
Irbesartan or Avapro is used in blood pressure control and can be used in combination with other drugs which also lower blood pressure, but care must be taken to ensure the blood pressure is not lowered too much so that postural hypotension results.
Medical Letter 1998:40(1019):18
The relevant product monographs must be regarded as the appropriate sources of prescribing information.