Troglitazone is used in the treatment of diabetes.
Troglitazone decreases insulin resistance by enhancing its activity in the liver, muscle, and fat cells. With more insulin activity, blood sugar is lowered.
Troglitazone is useful in Type II diabetes, that is, non insulin dependent diabetes, because some amount of insulin in the body is needed for its action. In Type I diabetes or insulin dependent diabetes, there is no insulin.
Troglitazone is well tolerated, however it may lower blood sugar levels too much - hypoglycemia.
People can decrease insulin resistance by loosing weight and exercising regularly, thus these activities are still important even if they use troglitazone.
Troglitazone in combination with any drug that can also lower blood sugar levels will result in hypoglycemia.
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Drugs Aging 1995;7(5):331
Diabetes Care 1996;19:151
The relevant product monographs must be regarded as the appropriate sources of prescribing information.