Becaplermin (Regranex) Drug for Diabetic Ulcers: Use, Side Effects, Interactions

Becaplermin
(Regranex, United States)

Use:

Becaplermin or Regranex is a growth factor used as an adjunct in the treatment of diabetic ulcers.

How It Works:

Becaplermin or Regranex is a recombinant human platelet-derived growth factor or rhPDGF which promotes the healing of ulcers. It is able to increase the proliferation of cells that repair wounds and form granulation tissue over a wound.
People with diabetes are prone to ulcer formation because of changes in circulation and pain perception - in fact ulcers can be so problematic that amputation may the only alternative.

Side Effects:

Becaplermin or Regranex is a gel which is applied to the ulcer, and the most reported side effects reflect this topical application - rash, infection, cellulitis.

Cautions for People:

Becaplermin or Regranex is applied once a day and covered with a saline moistened dressing. After 12 hours it is recommended that the gel be rinsed off and the wound re-covered. People who have manual dexterity problems or who would otherwise be unable to comply may find problems with the product.

Drug Interactions:

Further Reading:

Diabetes Care 1998;21:822

Added to Virtual Drugstore July 1998.

The relevant product monographs must be regarded as the appropriate sources of prescribing information.