Sparfloxacin or Zagam is a quinolone antibiotic used to treat pneumonia and bronchitis.
Sparfloxacin or Zagam interferes with bacterial DNA, and thus bacterial ability to reproduce. It is active against gram positive bacteria including penicillin resistant Strep pneumoniae.
Sparfloxacin or Zagam increases an individual's photosensitivity - so much so they are even at risk for sunburn from sun exposure through glass. Nausea and diarrhea have been reported.
Sparfloxacin or Zagam is a quinolone antibiotic and these antibiotics seem to be involved in joint problems, specifically tendinitis thus people at increased risk for this type of problem should be closely monitored.
Pregnant women and lactating mothers should use Sparfloxacin or Zagam with care.
In combination with drugs that can cause heart beat irregularities, for example terfenadine, Sparfloxacin or Zagam can also cause these heart beat irregularities - specifically a prolonged QT interval.
Given with theophylline, Sparfloxacin or Zagam can increase theophylline blood levels. It can also increase the effects of the anticoagulant warfarin.
Antacids or highly buffered drugs can reduce Sparfloxacin or Zagam's absorption. In fact taking Sparfloxacin or Zagam with an acidic beverage such as a cola drink may increase its absorption.
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Eur Respir J 1995;8:1999
Medical Letter 1997;39:41
The relevant product monographs must be regarded as the appropriate sources of prescribing information.