This article is from the Ergonomics and Typing Injury FAQ, by Dan Wallach email@example.com with numerous contributions by others.
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The Twiddler is both a keyboard and a mouse, and it fits in one hand. You
type via finger chords. Shift, control, etc. are thumb buttons. When in
"mouse" mode, tilting the Twiddler moves the mouse, and mouse buttons are
on your fingers.
The cabling leaves your normal keyboard available, also.
Most applications work, and Windows works fine. DESQview has trouble.
GEOWorks also has trouble - mouse works, keyboard doesn't. OS/2
compatibility coming soon.