31.18 How fast do solvents pass through human skin?
Description
This article is from the Chemistry FAQ, by Bruce Hamilton B.Hamilton@irl.cri.nz with numerous contributions by others.
31.18 How fast do solvents pass through human skin?
It obviously depends on the solvents, and traditional measurements have
been made using dead skin, but some recent work has provided a simple
comparison of individual solvents. It must be emphasised that mixtures of
solvents may have significantly different rates [29].
Permeability Constants in g/m2h
Solvent Average Standard Deviation
Dimethylsulfoxide 176 42
N-Methyl-2-pyrrolidone 171 59
Dimethylacetimide 107 19
Dimethylformamide 98 1.1
Methyl ethyl ketone 53 29
Methylene chloride 24 8.4
Water [^3H radiolabeled] 14.8 0.1
Ethanol 11.3 0.5
Butyl acetate 1.6 0.1
gamma butyrolactone 1.1 0.1
Toluene 0.8 0.7
Propylene carbonate 0.7 0.4
Sulfolane 0.2
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