This item is from the PC Hardware FAQ, by Willie Lim and Ralph Valentino with numerous contributions by others. (v1.25).
[From: cls@truffula.sj.ca.us (Cameron L. Spitzer)]
Sure. Even inferior operating systems can use it for something. The question is how much performance it buys. In ISA, the DMA channels and bus-mastering IO cards can only address the first 16 MB. Therefore the device drivers have to copy data up and down or just not use the space. I am told the Linux SCSI drivers know how to do this. I don't know about OS/2 or MSWindows.
 
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