This article is from the WINE WINdows Emulator FAQ, by Dave Gardner firstname.lastname@example.org with numerous contributions by others.
If you have a DOS partition, first make sure that you have mounted it,
either by putting the entry into /etc/fstab, or by manually mounting it.
Remember too that unless your version of UNIX can see through it, or you
are running a utility that can see through it, your DOS partition must not
be located on a Drivespaced, Doublespaced or Stackered partition, as
neither Linux, FreeBSD, NetBSD or Wine can natively 'see' files located in
these compressed DOS partitions.
Check your path statements in the wine.conf file. No capital letters may
be used in paths, as they are automatically converted to lowercase.