This article is from the WINE WINdows Emulator FAQ, by Dave Gardner email@example.com with numerous contributions by others.
All you have to do is to type:
rm -fR [/path/]Wine*
Make sure that you specify the exact path when using the powerful 'rm -fR'
command. If you are afraid that you might delete something important, or
might otherwise delete other files within your filesystem, cd into each
Wine subdirectory singly and delete the files found there manually, one
file or directory at a time. Neither the Wine developers and programmers,
nor the Wine FAQ author/maintainer, can be held responsible for your
deleting any files in your own filesystem.