Oxaprozin (Daypro) Drug for Rheumatoid Arthritis: Use, Side Effects, Interactions

Oxaprozin
(Daypro, United States and Canada)

Use:

Oxaprozin or Daypro is a non steroidal anti inflammatory drug used for inflammatory conditions such as rheumatoid arthritis.

How It Works:

Oxaprozin or Daypro inhibits an enzyme which decreases prostaglandin production and thus reduce inflammation.

Side Effects:

Oxaprozin or Daypro is a long acting non steroidal anti inflammatory and as such may have fewer side effects associated with it, however if a side effect occurs, it will be long acting as well.
Oxaprozin or Daypro can cause stomach irritation including ulcer perforation. It prolongs bleeding times and has been associated with fulminating hepatitis.

Cautions for People:

People with sensitive stomachs and/or ulcer disease may not be able to tolerate Oxaprozin or Daypro, and some people may be allergic to the drug. Because it has been associated with liver problems, people with liver disease should use Oxaprozin or Daypro only under medical supervision.

Drug Interactions:

Oxaprozin or Daypro prolongs bleeding times and thus can interact with anticoagulants. It has been reported to interact with benzodiazepines to precipitate panic disorders.

Further Reading:

J Pharm Pharmacol 1995;47(11):937
Clin Ther 1995;17(4):735
Ann Pharmacother 1994;28(10):1159
Am Fam Physician 1994;49(5):1197
Med Letter 1993;35(890):15

Added to Virtual Drugstore April 1997.

The relevant product monographs must be regarded as the appropriate sources of prescribing information.