Pramipexole or Mirapex is used in both early and late Parkinson's disease.
In Parkinson's disease, there is a deficiency of the neurochemical dopamine. Pramipexole or Mirapex is a dopamine agonist which stimulates dopamine receptors in the brain - acting like dopamine would.
Orthostatic hypotension - a drop in blood pressure when an individual stands up - and hallucinations have been reported with Pramipexole or Mirapex, although both more often occur in late Parkinson's disease. Nausea and drowsiness can occur.
People with late Parkinson's disease who have blood pressure problems should use Pramipexole or Mirapex with care. Because older people and people who are taking drugs which affect the nervous system are more at risk for hallucinations, they must use Pramipexole or Mirapex with close supervision. Pramipexole or Mirapex is excreted through the kidneys, and people with kidney disease may require a dosage adjustment.
In late Parkinson's disease Pramipexole or Mirapex may be used in combination with levodopa.
The Medical Letter 1997;39(1014):109
The relevant product monographs must be regarded as the appropriate sources of prescribing information.