Alendronate (Fosamax) Drug for Osteoporosis: Use, Side Effects, Interactions

Alendronate
(Fosamax, United States and Canada)

Use:

Alendronate or Fosamax is used to reduce bone loss in osteoporosis.

How It Works:

Alendronate or Fosamax decreases bone turnover - increasing bone formation while decreasing bone resorption by the body.

Side Effects:

Alendronate or Fosamax most common side effects are mild gastrointestinal disturbances.
A serious side effect that had been reported is ulceration of the esophagus. Taking the drug while standing or sitting up and with a full glass of water will ensure that the tablet does not "stick" in the esophagus to cause ulceration. Signs of this ulceration include any throat pain, difficulty swallowing, chest pain, and heart burn.

Cautions for People:

Both men and women have used Alendronate or Fosamax to reduce bone loss.

Drug Interactions:

Alendronate or Fosamax is poorly absorbed, and food blocks its absorption completely. It should be taken on an empty stomach, at least half an hour before eating, and only with water, not juice, not coffee.
To support an increase in bone formation, calcium and vitamin D supplementation may be needed.

Further Reading:

Am J Gastroenterol 1995;90:1889
Med Letter 1996;38:1

Added to Virtual Drugstore August 1996.

The relevant product monographs must be regarded as the appropriate sources of prescribing information.