Desmopressin (DDAVP) Drug for Diabetes Insipidus: Use, Side Effects, Interactions

Desmopressin
(DDAVP, United States and Canada)

Use:

Desmopressin or DDAVP is used in diabetes insipidus.

How It Works:

Diabetes insipidus is characterized by too high urine out put. Desmopressin or DDAVP is a synthetic structure similar to the body's antidiuretic hormone which is responsible for the retention of fluids in the kidney. Desmopressin or DDAVP alters the permeability of kidney tissues and increases the kidney's reabsorption of water, thus reducing the urine output.

Side Effects:

Desmopressin or DDAVP is generally well tolerated. Headache and nausea are sometimes seen, but adjusting the dose will usually solve these side effects.
Desmopressin or DDAVP is available as a nasal spray for children's bed wetting, and is an alternative to the tablets.

Cautions for People:

Because Desmopressin or DDAVP causes the body to retain water, water intoxication is a possibility. Very young and very old people are most susceptible to this effect, and should watch their fluid intake to avoid this problem.

Drug Interactions:

Desmopressin or DDAVP can affect drugs that are excreted through the kidneys.

Further Reading:

J Clin End Metabolism 1986;63:129
Arch Disease in Child 1986;61:247
Clin Endocrinol 1986;24:253

Added to Virtual Drugstore August 1996.

The relevant product monographs must be regarded as the appropriate sources of prescribing information.