Divalproex Sodium, Depakote or Epival is an anticonvulsant used in epilepsy, but also is finding use in migraine headache prevention and some psychiatric conditions.
Divalproex Sodium, Depakote or Epival is thought to act by increasing levels of a neuro transmitter known as gamma aminobutyric acid or GABA. The net result is restoration of the neuro chemicals in the nervous system to more close to normal levels.
Divalproex Sodium, Depakote or Epival is taken regularly for migraine headache prevention, but is reserved for cases where other therapies - beta blockers, tricyclic antidepressants, non steroidal anti inflammatory drugs, verapamil - have failed.
Divalproex Sodium, Depakote or Epival is also reserved for use in psychiatric conditions - bipolar mania disorder - when other therapies have failed.
Divalproex Sodium, Depakote or Epival is generally well tolerated, but nausea, tremor, indigestion, and weight gain have been reported. These side effects disappear with time.
Divalproex is reserved for people with migraine headaches or psychiatric conditions that have not responded to other therapies.
Because divalproex is metabolized in the liver, it is able to interact with any drug that is also metabolised in the liver, either reducing or increasing blood levels.
Arch Neurol 1995;52:281
Med Letter 1994;36:74
The relevant product monographs must be regarded as the appropriate sources of prescribing information.