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Nisolidipine (Sular) Drug for High Blood Pressure: Use, Side Effects, Interactions




Nisolidipine
(Sular, United States and Canada)

More drugs used for High Blood Pressure.

Use:

Nisolidipine or Sular is a calcium channel blocker used in cardiovascular conditions such as high blood pressure.
It is structurally similar to nifedipine and is available as an extended release preparation meaning that once a day dosing is possible to increase compliance and avoid fluctuations in blood pressure control.

How It Works:

Nisolidipine or Sular impedes the movement of calcium ions in vascular smooth muscle - blood vessel walls - and cardiac muscle. By doing so it relaxes these muscles resulting in vasodilation.

Side Effects:

Nisolidipine or Sular can cause dizziness, headache, peripheral edema, and tachycardia. Facial flushing may be bothersome. Dental hygiene must be meticulous because Nisolidipine or Sular can cause gingival hyperplasia.

Cautions for People:

Because Nisolidipine or Sular is metabolised in the liver, people with liver disease and/or elderly people need lower doses.

Drug Interactions:

Grapefruit juice, fatty meals, and drugs like cimetidine can increase Nisolidipine or Sular's absorption and toxicity.

Further Reading:

Med Letter 1996;38(968):13
JAMA 1995;274:620
Ann Intern Med 1995;123:888

Added to Virtual Drugstore November 1996.

The relevant product monographs must be regarded as the appropriate sources of prescribing information.













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