Atorvastatin (Lipitor) Drug for Cholesterol: Use, Side Effects, Interactions

Atorvastatin
(Lipitor, United States and Canada)

Use:

Atorvastatin or Lipitor is a lipid lowering drug which is able to lower low density lipoproteins up to 60%, compared to 20-40% for other lipid lowering drugs. It also significantly lowers triglyceride levels - up to 40%

How It Works:

Atorvastatin or Lipitor is a "statin" which is able to inhibit an enzyme in the body responsible for the manufacture of lipids

Side Effects:

Atorvastatin or Lipitor is generally well tolerated, however it can cause constipation, diarrhea, indigestion, gas, and nausea. Some people may experience headache or muscle aches.

Cautions for People:

Because Atorvastatin or Lipitor can affect both the liver and kidney, people with conditions of either organ must use this drug with care. It is recommended that older people - over 65 years of age - should use the lowest effective dose possible.

Drug Interactions:

In combination with other types of cholesterol lowering drugs, Atorvastatin or Lipitor has an additive effect. In combination with digoxin or erythromycin close monitoring is needed to avoid adverse effects.

Further Reading:

JAMA 1996;275:128
Ann Intern Med 1996;125:529
J Cardiovasc Pharmacol Ther 1996;1(2):117
Atherosclerosis 1996;119(2):203
J Clin Pharmacol 1996;36(4):356

Added to Virtual Drugstore April 1997.

The relevant product monographs must be regarded as the appropriate sources of prescribing information.