Topotecan (Hycamtin) Drug for Cancer: Use, Side Effects, Interactions

Topotecan
(Hycamtin, United States and Canada)

Use:

Topotecan or Hycamtin is used for ovarian cancer.

How It Works:

Topotecan or Hycamtin is a member of a group of drugs known as camptothecins or topoisomerase I inhibitors. By inhibiting this enzyme, DNA damage occurs in the cells when they replicate.

Side Effects:

Topotecan or Hycamtin is considered second line therapy after cisplatin or paclitaxel for advances ovarian cancer because of severe neutropenia. While it does seem to work better than paclitaxel, the severity of this blood disorder side effects limits its use.

Cautions for People:

Because of the potential severe blood disorder, people taking Topotecan or Hycamtin must be followed closely.

Drug Interactions:

Topotecan or Hycamtin is used in combination with other drugs for ovarian cancer treatment, however it must be used with caution in combination with any other drugs that may cause blood disorders.

Further Reading:

FDC Reports 1996;58(23):3
Drugs 1995;49:11

Added to Virtual Drugstore November 1996.

The relevant product monographs must be regarded as the appropriate sources of prescribing information.