Bicalutamide or Casodex is use in metastatic prostate cancer, that is prostate cancer which has spread to other areas of the body.
Bicalutamide or Casodex is an anti androgen, meaning it blocks male hormones - specifically, testosterone. It is given in combination with either a drug that inhibits the production of testosterone, for example leuprolide, goserelin, or with surgical castration. This therapy means that the body does not produce male hormones, and whatever amounts do exist in the body are blocked by Bicalutamide or Casodex.
Bicalutamide or Casodex can cause breast enlargement, hot flashes, itching, and breast tenderness. Because Bicalutamide or Casodex is not a steroid drug, it does not have side effects associated with steroids.
Bicalutamide or Casodex is metabolised in the liver. With liver damage more of the drug may remain in the body, thus people with liver damage should take the drug with care.
Women and children should not take Bicalutamide or Casodex.
Bicalutamide or Casodex is often given with other drugs to obtain a maximum therapeutic effect.
N Engl J Med 1994;331:996
The relevant product monographs must be regarded as the appropriate sources of prescribing information.