Adapalene or Differin is a topical retinoid used for acne.
Adapalene or Differin exfoliates the skin, in effect "removing" the acne. Several weeks are required to see improvement.
Adapalene or Differin is related to other retinoids such as tretinoin.
Skin irritation is a common side effect of all retinoids, however Adapalene or Differin is less likely to cause this skin irritation.
Adapalene or Differin like all retinoids does increase the skin's sensitivity to the sun. Wear sun screen. Applying it at night will reduce sun sensitively.
If skin irritation does occur, stopping Adapalene or Differin will resolve it, or even applying it less often.
People with sensitive skin should avoid Adapalene or Differin as well as all retinoids.
Concurrent use of drugs which increase skin sensitivity should be avoided.
Skin Pharmacol 1993;6(Suppl1):61
FDC Reports 1996;58(8):21
The relevant product monographs must be regarded as the appropriate sources of prescribing information.