This article is from the Interpretation Of Lab Test Profiles, by Ed Uthman email@example.com with numerous contributions by others.
Thrombocytosis is seen in many inflammatory disorders and
myeloproliferative states, as well as in acute or chronic blood
loss, hemolytic anemias, carcinomatosis, status
post-splenectomy, post- exercise, etc.
Thrombocytopenia is divided pathophysiologically into
production defects and consumption defects based on examination
of the bone marrow aspirate or biopsy for the presence of
megakaryocytes. Production defects are seen in Wiskott-Aldritch
syndrome, May-Hegglin anomaly, Bernard-Soulier syndrome,
Chediak-Higashi anomaly, Fanconi's syndrome, aplastic anemia
(see list of drugs, above), marrow replacement, megaloblastic
and severe iron deficiency anemias, uremia, etc. Consumption
defects are seen in autoimmune thrombocytopenias (including ITP
and systemic lupus), DIC, TTP, congenital hemangiomas,
hypersplenism, following massive hemorrhage, and in many severe