This article is from the Interpretation Of Lab Test Profiles, by Ed Uthman firstname.lastname@example.org with numerous contributions by others.
Globulin is increased disproportionately to albumin
(decreasing the albumin/globulin ratio) in states characterized
by chronic inflammation and in B-lymphocyte neoplasms, like
myeloma and Waldenström's macroglobulinemia. More relevant
information concerning increased globulin may be obtained by
serum protein electrophoresis.
Decreased globulin may be seen in congenital or acquired
hypogammaglobulinemic states. Serum and urine protein
electrophoresis may help to better define the clinical problem.