This article is from the Interpretation Of Lab Test Profiles, by Ed Uthman uthman@neosoft.com with numerous contributions by others.
Increase in serum total protein reflects increases in albumin,
globulin, or both. Generally significantly increased total
protein is seen in volume contraction, venous stasis, or in
hypergammaglobulinemia.
Decrease in serum total protein reflects decreases in albumin,
globulin or both [see "Albumin" and "Globulin, A/G ratio,"
below].
 
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