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11 CREATININE




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This article is from the Interpretation Of Lab Test Profiles, by Ed Uthman uthman@neosoft.com with numerous contributions by others.

11 CREATININE

Increase in serum creatinine is seen any renal functional
impairment. Because of its insensitivity in detecting early
renal failure, the creatinine clearance is significantly reduced
before any rise in serum creatinine occurs. The renal impairment
may be due to intrinsic renal lesions, decreased perfusion of
the kidney, or obstruction of the lower urinary tract.

Nephrotoxic drugs and other chemicals include:

   antimony          arsenic              bismuth          cadmium 
   copper            gold                 iron             lead
   lithium           mercury              silver           thallium
   uranium           aminopyrine          ibuprofen        indomethacin
   naproxen          fenoprofen           phenylbutazone   phenacetin
   salicylates       aminoglycosides      amphotericin     cephalothin
   colistin          cotrimoxazole        erythromycin     ampicillin
   methicillin       oxacillin            polymixin B      rifampin
   sulfonamides      tetracyclines        vancomycin       benzene 
   zoxazolamine      tetrachloroethylene  ethylene         glycol 
   acetazolamide     aminocaproic acid    aminosalicylate  boric acid
   cyclophosphamide  cisplatin            dextran (LMW)    furosemide
   mannitol          methoxyflurane       mithramycin      penicillamine 
   pentamide         phenindione          quinine          thiazides
   carbon tetrachloride

Deranged metabolic processes may cause increases in serum
creatinine, as in acromegaly and hyperthyroidism, but dietary
protein intake does not influence the serum level (as opposed to
the situation with BUN). Some substances interfere with the
colorimetric system used to measure creatinine, including
acetoacetate, ascorbic acid, levodopa, methyldopa, glucose and
fructose. Decrease in serum creatinine is seen in pregnancy and
in conditions characterized by muscle wasting.

 

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