11 CREATININE
Description
This article is from the Interpretation Of Lab Test Profiles, by Ed Uthman uthman@neosoft.com with numerous contributions by others.
11 CREATININE
Increase in serum creatinine is seen any renal functional
impairment. Because of its insensitivity in detecting early
renal failure, the creatinine clearance is significantly reduced
before any rise in serum creatinine occurs. The renal impairment
may be due to intrinsic renal lesions, decreased perfusion of
the kidney, or obstruction of the lower urinary tract.
Nephrotoxic drugs and other chemicals include:
antimony arsenic bismuth cadmium copper gold iron lead lithium mercury silver thallium uranium aminopyrine ibuprofen indomethacin naproxen fenoprofen phenylbutazone phenacetin salicylates aminoglycosides amphotericin cephalothin colistin cotrimoxazole erythromycin ampicillin methicillin oxacillin polymixin B rifampin sulfonamides tetracyclines vancomycin benzene zoxazolamine tetrachloroethylene ethylene glycol acetazolamide aminocaproic acid aminosalicylate boric acid cyclophosphamide cisplatin dextran (LMW) furosemide mannitol methoxyflurane mithramycin penicillamine pentamide phenindione quinine thiazides carbon tetrachloride
Deranged metabolic processes may cause increases in serum
creatinine, as in acromegaly and hyperthyroidism, but dietary
protein intake does not influence the serum level (as opposed to
the situation with BUN). Some substances interfere with the
colorimetric system used to measure creatinine, including
acetoacetate, ascorbic acid, levodopa, methyldopa, glucose and
fructose. Decrease in serum creatinine is seen in pregnancy and
in conditions characterized by muscle wasting.
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