This article is from the Interpretation Of Lab Test Profiles, by Ed Uthman email@example.com with numerous contributions by others.
Increase in serum creatinine is seen any renal functional
impairment. Because of its insensitivity in detecting early
renal failure, the creatinine clearance is significantly reduced
before any rise in serum creatinine occurs. The renal impairment
may be due to intrinsic renal lesions, decreased perfusion of
the kidney, or obstruction of the lower urinary tract.
Nephrotoxic drugs and other chemicals include:
antimony arsenic bismuth cadmium copper gold iron lead lithium mercury silver thallium uranium aminopyrine ibuprofen indomethacin naproxen fenoprofen phenylbutazone phenacetin salicylates aminoglycosides amphotericin cephalothin colistin cotrimoxazole erythromycin ampicillin methicillin oxacillin polymixin B rifampin sulfonamides tetracyclines vancomycin benzene zoxazolamine tetrachloroethylene ethylene glycol acetazolamide aminocaproic acid aminosalicylate boric acid cyclophosphamide cisplatin dextran (LMW) furosemide mannitol methoxyflurane mithramycin penicillamine pentamide phenindione quinine thiazides carbon tetrachloride