This article is from the the official alt.spleen FAQ, by Andrew Stellman with numerous contributions by others.
Andrew says: NOTE: PLEASE DO NOT SEND ANY MAIL TO ME REQUESTING MEDICAL ADVICE! I AM NOT A DOCTOR, AND WILL NOT GIVE YOU ANY USEFUL INFORMATION.
Researcher Wintermute (firstname.lastname@example.org) writes:
"The whole reaso trephination was invented was to make squicking easier. While crude brain-surgery, and altering one's mind are noble pastimes, don't forget why Trephination was invented. Can you imagine what squickers did before the invention of drills? It must have been hell trying to slowly whittle away at or hammer a hole in the skull of their partner.
"Now as everyone knows, spam was invented as a substitute for brain matter. Only real brains will do for a good squicking, but sometimes a squicking-addict finds himself in a location where no brains are readily available (a college frathouse for example). For this reason, spam was invented. In fact, the original development name for the product we all know as spam was, 'I Can't Believe It's Not Cranial Tissue'. Try it sometime. Drill a hole in a large tin of spam and pork (heh) till your heart's content."