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121 What is the life expectancy of an LR kidney transplant?




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This article is from the Organ Transplant FAQ, by mike_holloway@hotmail.com (Michael Holloway) with numerous contributions by others.

121 What is the life expectancy of an LR kidney transplant?

Question:
I had a Kidney transplant in 1989. The Kidney was from my sister. Is
there an expected life to a transplant or is the life range not known?
In other words can one say that a LRD kidney tranplant have an
expected life of 5-10 years or 10 to 15 etc.?

Answer:
Each of us inherits half of our genes from our mother and half from our
father. The genes responsible for immunological reactions to transplanted
organs are close to each other on a single chromosome; so, for the most
part, they are inherited as a single group, called a haplotype. If
siblings recieve the same group of genes from each parent, they are a
two-haplotype (full or complete) match. If they receive one group that is
the same and one group that is different, they are a one-haplotype (half)
match. If both groups of genes are different they are a zero haplotype
match.

In general, two-haplotyped matched living related donor kidney
transplants have a 50% chance of achieving 24 years of function,
one-haplotyped matched living related donor kidney transplants have a 50%
chance of achieving 12 years of function, and cadaver donor kidney
transplants have a 50% chance of achieving 9 years of function (Cecka and
Terasaki, "The UNOS Scientific Renal Transplant Registry", Clinical
Transplants 1993, Paul I Terasaki and JM Cecka, eds., UCLA Tissue Typing
Registry, 1993:1-18). This does not mean, for example, that a
two-haplotype matched living related transplant will function for 25
years and then fail, or that a cadaveric donor transplant will last 9
years and fail. Any individual transplant, if well cared for, may last
much longer.

Alan Leichtman, MD (University of Michigan)
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