* Enough time with high enough mercury load just simply CAN DEPLETE the liver of all sulfhydryls, the place where practically most or all of the SH-containing peptides/proteins/enzymes whatever way you like to call those are built/synthesized, with some additional external local organ-system specific refinement of the compounds containing SH-groups. I wouldn't look only to the ApoE's, though they are a part of the bigger picture.

* From: Ray S. <mercure@PRIMENET.COM>

I would say that it is more important to consider the ENERGY TRANSFER inhibition caused by mercury to Cytochrome C ensymes where there are DiTHiols present, like sulphite oxidase. It is a known fact that Cyto B levels are very high in mercury poisoned people due to Cyto C enzymes are blocked. This causes severe energy / electron transport chain blockade leading to less power to the most power hungry organ in the body, the brains. I think this is what Dr Haley's Studies found out related to the Alzheimers.

Now, one may have genetic reason not to be able to produce no more ApoE with SH;s in it, but it can as well be ACQUIRED, as mercury accumulation can cause ALMOST TOTAL depletion of the SH's from the body, leading to the same results. In my personal case, I sustained HUGE loads of mercury for almost 30 years, and finally an absolute overload brought the GSH-pools on their knees, leading to 60 % reduction of free SH-groups in my blood before and during the removal, meaning that mercury fillings are able to keep the SH-pools so low that body has to replace the SH-groups with something else, even in the absence of any GENETIC component.

......

Since my last writing about poor sulphoxidation and it's connection to reactions to sulfa-class antibiotics, DMPS (natriumsulphonate), PABA, some epilepsy drugs etc., I have received very interesting and promising data from a few other persons that got also side-effect from DMPS and whom also were sulfa-allergic/intolerant since they got their amalgams, plus having also inherited such reactivity. The information I have gathered from several DMPS side-effect/sulfa-intolerant with also severe mercury poisonings, clearly shows that each of these person's, including me have ELEVATED cysteine/sulfate ratio, which is suggestive of poor sulphoxidation, the inability to oxidate sulphites and to generate sulphate from cysteine...

The side-effects from sulfa and sulfonyl-groups etc. and PABA analogs has been common in people with poor sulfoxidation, as well as it seems to be so that it POOR SULPHOXIDATION IS COMMON in people with Alzheimer's, Parkinson's, rheumatoid arthritis and Motor Neuron Disease. I have source material to point that out if someone is not believing, for example KIP or Marvin B.

So, there is definitely reason to believe that the DETOXIFICATION, Liver and Gall are very ey, explaining why some people get very very sick from mecury, as they can no more excrete it out due to their detox system breakdown, whether due to excess mercury causing overload depleting the key enzyme co-factors like Molybdenum, B12, Folic acid, OR acquired (due to mercury) functional deficiency of the enzyme, which DOES contain 2 thiols, or aqcuired or inborn genetic deficiency of the sulphite oxidase, causing the poor sulphoxidation. This could lead to accumulation of poisons, and to bad side-effects from agents like sulfa-antibiotics, DMPS, PABA and foods like Red Wine, some beers and some franks that contain suplhites, or any food actually containing sulphites.

I encourage each and every MD, DDS, Naturopath, researcher, reader of this list with mercury poisoning etc. to test for the poor sulphxoxidation, and address the problem with right nutritional supplements, in case the situation is found to be poor... Elevated cysteine/sulphate ratio is suggestive of poor sulphoxidation, as well as low urine sulphate/creatitine ratio (have both) as well as reactions/intolrance to sulphites from Red Wine etc, side-effects from DMPS, PABA, SULFA-antibiotics etc.

Supplementation with Folate, B12 and molybdenum may well be a new combination improving the cases of Alzheimers, Parkinsons, MS etc. by normalizing the sulfur-metabolism, allowing also NAC etc products to work right in the body, by generating GSH and sulphates instead of just causing elevated cysteine in the blood ...

Well, there you have at least one NEW key idea to the issue. I wanted to write about this as I beleive it is my original idea to figure out WHY DMPS/SULFA/PABA reacts with people who have mercury poisoning, as the mercury has probably caused deficiency of the 2-thiol containing oxidase-enzyme needed for the sulphation, which is of course not necessarily inborn, but due to excess mercury eventually bringing the liver on it's knees, accumulating in excess after the "back is broken" and then disabling the sulphation/sulphoxidation due to direct binding to the small amounts of the necessary enzyme containing the thiols ...Of course, other mechanisms are propably also causing the enzyme damage, but the key is, one needs to look at this issue, and try to correct the issue with nutrition... This idea is MY gift to you, based on my 5 years of studying. It is not MUCH, but it is a start. I think I have stumbled and found an important key puzzle in the liver-blockage related to mercury. Once that piece is working, the other mechanisms and minerals and such just might have a change to work better. In case the situation can not be helped with minerals, then even genetic engineering might be needed to recover the enzyme synthesis provided there is no more mercury in the liver causing the disablement of the enzymes...

Checking for porphyria at the same time makes a lot of sense to me also biochemically, as it seems to be very closely connected to electron transport chain blockages as this one, and related to the dithiol-enzymes and their inhibition, and related to metal-carrying/ oxidating proteins ...

There is evidence that high dose B12/Folate/Molybdenum can make miracles happen to some of of the poor sulphoxidizers in the long term with persisted supplementation, incase the enzyme deficiency was due to low molybdenum or B12/folate, even in case this combimation might elevate organic mercury, I think the problem of blocked detoxing is much worse than small amount of the FREE mercury converted to methyl-mercury.

As most mercury is bound deep in the tissue, there should be minimal mercury methylation happening due to the supplementation of the sulphate oxidase enzyme cofactors. I encourage people to have liver function panels / organic acid panels, or some other panels measuring the sulphate and cysteine levels done.

That way we could bring out much more cases of poor sulphoxidation to the public, raise the awereness of the importance studying this issue in larger scale, and maybe something more could be done to address the problem, and also, to gain more understanding also of the other mercury related inhibitions of liver/gall metabolic processes.

IN UK as well as in Sweden, there have already been studies linking Poor S.O. to the arthritis, lupus etc. autoimmune diseases etc. Also, some even older US research articles show practically most EVERY rheumatoid arthritis patient they studied had VERY low blood SH-status, high levels of excess haevy metals like copper, mercury and lead, plus abnormal picture of antibodies, and generally deranged sulfur metabolism.

My belief, based on the amount of material I have read, the most difficult cases of mercury poisoning with complications that exhibit in Parkinson's/Alzheimers/Chronic Cirrhosis/Arthritis/Polyneuropathy (etc.) -type conditions are probably all related to the poor sulphoxidation, related deficient heavy metal detoxification in the presence of excess heavy metal load in the body, like mercury/copper-amalgams in the oral cavity. You then get low GSH status depleted by the metal, either damaged sulphite oxidation enzymes due to direct effect of excess metals, or inherited or acquired reasons, either genetic or nutritional due for example the previously mentioned deficiencies of molybdenum, folate, B12 etc. And, additionally probably cirhotic/choleostatic condition, blocked gall, lowered bile production, abnormal contents of bile, with low sulphates and glutathione conjugates in the bile, possibly also some mercury related damage to pancreas, causing impaired glucuronic acid formation, as well as damage to enzymes like lipase etc. forming a very complex situation, leading to myriad of other problems, like hormonal imbalance due to impaired sulphation and removal of the hormones etc. "backing up" of the metal into the nerves etc.

Complex, and interesting picture. And I think my idea, which may not be totally fresh, but at least it is important one, is agreeing very well with Huggins's "poor detoxifiers" whom propably could be called also "poor sulfoxidizers" as well, without more studies, I can not tell, but at least I can tell that related to DMPS/sulfa-side-effects and intolerances, looks like S.O is some kind of an important parameter ...

Hope this sulphoxidation issue would get more interest,as I do strongly believe trough that issue people and MD's just might get after the important issues, mercury and liver biochemical pathways, and how to correct the problems with nutrition, as well as to test enzyme functional deficiencies, and to study what could be done to recover such damaged missing enzymes ...

Also make sure to read these books: Poison in Your Teeth: Mercury Amalgam (Silver) Fillings...Hazardous to Your Health! and Mercury Detoxification by Tom McGuire