This article is from the Isaac Asimov FAQ, by Edward J. Seiler ejseiler@earthlink.net and John H. Jenkins jenkins@mac.com with numerous contributions by others.
Asimov wrote the novel from the screenplay. He made a certain number of
changes which he felt were necessary to minimize the scientific
implausibility of the story. Because, as he put it, he wrote quickly and
Hollywood works slowly, the novel came out some six months before the film
was released, giving rise to the idea that the movie was made from the
novel.
Asimov was never satisfied with Fantastic Voyage , and he never thought
of it as "his" work. Later, a person who had bought the rights to the
title and concept (but not the characters or situation) of the original
was interested in making Fantastic Voyage II . Naturally he turned to
Asimov, who at first refused. At some point, Asimov agreed, but insisted
on handling his side as a pure book deal with Doubleday. Consequently,
Asimov's book Fantastic Voyage II should not be considered a sequel to
the original.
 
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