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8.3 References on breastfeeding and baby allergies


This article is from the Children Allergies and Asthma FAQ, by Eileen Kupstas Soo kupstas@cs.unc.edu with numerous contributions by others.

8.3 References on breastfeeding and baby allergies

Contributor: Paula Burch (pburch@bcm.tmc.edu)

AN 91179769. 91000.
AU Haschke-F. Pietschnig-B. Bock-A. Huemer-C. Vanura-H.
IN Universitats-Kinderklinik Wien.
TI `Does breast feeding protect from atopic diseases?:.
SO Padiatr-Padol. 1990. 25(6). P 415-20.
AB It is well established that food antigens can pass from mothers to
infants via the breast milk. Bovine-beta-lactoglobulin has been
detected in several breast milk samples from mothers with regular
intake of *cow's* milk. Healthy *breastfed* infants can produce IgG
antibodies against *cow's* milk protein and in infants at risk for
atopic disease specific IgE antibodies were found before *cow's* milk
based infant formula was introduced into the diet. However, several
clinical studies in infants at risk for atopic disease indicate that
exclusive breastfeeding decreases the incidence of atopic disease.

The protective effect of breastfeeding is only relative and it is
uncertain, how long protection lasts. Sensitization to food antigens
may occur already in utero, because infants whose mothers avoid
common allergenic foods during the whole pregnancy and then during
the lactation period have a lower incidence of atopic eczema than
infants whose mothers are on an unrestricted diet. Avoidance of
common allergenic foods only during the last trimester of pregnancy
had no effect, because the fetus is capable of forming IgE immune
response. Author-abstract. 17 Refs.

AN 88217424. 88000.
AU Taubman-B.
IN Division of Gastroenterology and Nutrition, Children's Hospital of
Philadelphia, PA.
TI Parental counseling compared with elimination of *cow's* milk or soy
milk protein for the treatment of infant *colic* syndrome: a randomized
SO Pediatrics. 1988 Jun. 81(6). P 756-61.
AB Treating the infant *colic* syndrome by counseling the parents
concerning more effective responses to the infant crying is compared
to the elimination of soy or *cow's* milk protein from the infant's
diet in a randomized clinical trial. Because symptoms of vomiting
and diarrhea are not part of the infant *colic* syndrome, infants with
these gastrointestinal symptoms were excluded from the study.
Dietary changes were accomplished by either feeding the infants a
hydrolyzed casein formula or by requiring mothers to eliminate milk
from their diets. In phase 1 of the study, the group receiving
counseling (n = 10) had a decrease in crying from 3.21 +/- 1.10 h/d
to 1.08 +/- 0.70 h/d (P = .001). The crying in the group that
received dietary changes (n = 10) decreased from 3.19 +/- 0.69 h/d to
2.03 +/- 1.07 h/d (P = .01), a level still greater than twice normal.

AN 89189856. 89000.
TI *Cow's* milk allergy in the first year of life. An Italian
Collaborative Study.
SO Acta-Paediatr-Scand-Suppl. 1988. 348. P 1-14.
AB The diagnosis of *Cow's* Milk Protein Allergy was considered in 303
infants aged less than 1 year, who presented with one or more of the
following symptoms: acute reaction related to *cow's* milk proteins
(CMP) ingestion, severe *colics,* persisting vomiting, protracted
diarrhea with or without blood and mucus, failure to thrive, eczema,
respiratory symptoms, such as chronic rhinitis and wheezing. A
diagnosis of CMPA was confirmed in 148 cases (60%): 125 relapsed on
milk challenge, 23 were not challenged because of acute reactions at
onset, presence of specific IgE (RAST and prick), and improvement on
milk free diet. Familial atopy, familial history of CMPA and
previous acute gastroenteritis were significantly more frequent in
cases than in 191 age matched controls. Breast feeding was not more
common or of longer duration in controls, compared to cases. Mean
IgE serum levels were higher (46.3 U/ml) in cases than in controls
(17 U/ml), while specific *Cow's* Milk Protein IgE were found in 71/148
cases (48%). 15 infants entered the study while on breast milk,
because of the confirmed relation between their symptoms and CMP on
the maternal diet. These infants had a higher prevalence of IgE
mediated problems. All cases improved on a milk free diet but in 26
(17.8%) a further modification of the diet was required after the
first prescription. Milk challenge was monitored by simple
laboratory tests: all cases who had symptoms on challenge showed at
least one test modification. Six infants, with no history of acute
reaction, showed severe self-limited clinical symptoms at challenge.
Key words: *cow's* milk allergy, milk, allergy, prick test, eczema,
diarrhea. Author-abstract.

AN 91187523. 91000.
AU Clyne-P-S. Kulczycki-A Jr.
IN Washington University School of Medicine, St Louis, Missouri.
TI Human breast milk contains bovine IgG. Relationship to infant *colic?*
SO Pediatrics. 1991 Apr. 87(4). P 439-44.
AB Previous studies have suggested that an unidentified *cow's* milk
protein, other than beta-lactoglobulin and casein, might play a
pathogenetic role in infant *colic.* Therefore, a radioimmunoassay was
used to analyze human breast milk and infant formula samples for the
presence of bovine IgG. Milk samples from 88 of the 97 mothers
tested contained greater than 0.1 micrograms/mL of bovine IgG. In a
study group of 59 mothers with infants in the *colic-prone* 2- to
17-week age group, the 29 mothers of colicky infants had higher
levels of bovine IgG in their breast milk (median 0.42 micrograms/mL)
than the 30 mothers of noncolicky infants (median 0.32 micrograms/mL)
(P less than .02). The highest concentrations of bovine IgG observed
in human milk were 8.5 and 8.2 micrograms/mL. Most *cow's* milk-based
infant formulas contained 0.6 to 6.4 micrograms/mL of bovine IgG, a
concentration comparable with levels found in many human milk
samples. The results suggest that appreciable quantities of bovine
IgG are commonly present in human milk, that significantly higher
levels are present in milk from mothers of colicky infants, and that
bovine IgG may possibly be involved in the pathogenesis of infant
*colic.* Author-abstract.


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