This article is from the Mastiffs Breed FAQ, by mmcbee@access.mountain.net (Mike McBee) with numerous contributions by others.
Mastiffs are probably about average when it comes to the number of
hereditary health problems that they are prone to. Being a large
breed they are very prone to joint problems. For more information
on genetic problems, please refer to Appendix F.
+ Potentially life threatening or serious:
(*these conditions may be inherited or in some cases
acquired)
o Joint: hip dysplasia; elbow dysplasia (ununited anconeal
process, fragmented coronoid process, degenerative joint
disease); osteochondritis dissecans (OCD) of the
shoulders, knees, elbows or hocks.
o Eye problems that cause blindness: cataracts*, retinal
dysplasia with detachment, glaucoma., progressive
retinal atrophy (PRA)
o Other inherited eye problems: geographic retinal
dysplasia, PPM, entropion.
o Hypothyroidism*, immune deficiencies.
o Wobblers syndrome.
o Skin: demodectic mange, deep pyoderma.
o Nervous system: myasthenia gravis*, muscular dystrophy*,
epilepsy*
o Other: cardiomyopathy*, leukemia.
+ Less serious and/or less common:
(*these conditions may be inherited or in some cases
acquired)
o Eye problems: ectropion, iris cysts, macroblapharon
(haw), corneal dystrophy*, distichiasis, cherry eye, dry
eye, retinal folds.
o Skin: allergies
o Joint problems: HOD (hypertrophic Osteo Dystrophy),
degenerative joint disease*, arthritis*, spondylosis of
the spine.
o Reproductive: cryptorchid, monorchid, vaginal
hyperplasia.
o Heart: murmurs*, pulmonic stenosis.
o Other: hernias, von Willebrands Disease (vWD).
 
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