This article is from the Juvenile Renal Disease, by Susan L. Fleisher
Contributed by Maria Unson, firstname.lastname@example.org
* Thomas DA.
+ Juvenile renal disease in a dobermann [letter].
+ Veterinary Record, 1984 Oct 27, 115(17):446-7.
* DiBartola SP; Chew DJ; Boyce JT.
+ Juvenile renal disease in related Standard Poodles.
+ Journal of the American Veterinary Medical Association, 1983
Sep 15, 183(6):693-6.
+ Abstract: Chronic renal failure was diagnosed in 6 young
Standard Poodles from 2 related litters. Clinically, the
disease was characterized by polydipsia, polyuria, anorexia,
lethargy, vomiting, and bony deformities suggestive of
fibrous osteodystrophy. Laboratory evaluation revealed
azotemia and hypercholesterolemia in all 6 dogs and
nonregenerative anemia in 3 dogs. Two dogs had
hyperphosphatemia and another 2 were hypercalcemic.
Isosthenuria and proteinuria were found in both dogs for
which urinalyses were available. The kidneys were
characterized pathologically by interstitial fibrosis,
variable interstitial infiltrates of lymphocytes and plasma
cells, tubular atrophy, tubular dilatation, tubular basement
membrane mineralization, cystic glomerular atrophy, and
immaturity of glomeruli, with inconspicuous capillary lumens.
* Chew DJ; DiBartola SP; Boyce JT; Hayes HM Jr; Brace JJ.
+ Juvenile renal disease in Doberman Pinscher dogs. Journal of
the American Veterinary Medical Association, 1983 Mar 1,
+ Abstract: Renal failure was diagnosed in 22 young Doberman
Pinscher dogs. The clinical findings were anorexia, weight
loss, vomiting, lethargy, polydipsia, polyuria, and
dehydration. Laboratory findings were azotemia,
hyperphosphatemia, lymphopenia, nonregenerative anemia,
hypercholesterolemia, and proteinuria. The kidneys were
characterized pathologically by glomerular sclerosis, cystic
glomerular atrophy, tubular dilatation, tubular atrophy,
mononuclear interstitial inflammation, interstitial fibrosis,
interstitial mineralization, and hyperplasia of the
collecting duct epithelium.
* Picut CA; Lewis RM.
+ Juvenile renal disease in the Doberman Pinscher:
ultrastructural changes of the glomerular basement membrane.
Journal of Comparative Pathology, 1987 Sep, 97(5):587-96.
+ Abstract: Ten cases of juvenile renal disease in Doberman
Pinschers were examined by light microscopy and 8 of them
additionally by electron microscopy. Two distinct basic
ultrastructural lesions of the glomerular basement membrane
(GBM) were observed. One is characterized by lamellation of
the lamina densa with intramembranous focal areas of lucency
containing electron-dense particles, the second by diffuse
attenuation of the lamina densa with intramembranous and/or
subendothelial deposition of matrix entrapping cross-banded
fibres (collagen). Based on similar ultrastructural changes
in other hereditary nephropathies in man and dogs, a
metabolic or biochemical basis for the structural lesions is
* Rosenbruch M., [Pathomorphology of so-called juvenile renal
disease in the dog].
+ Zentralblatt fur Veterinarmedizin. Reihe A, 1986 Mar,
33(3):193-207. Language: German.
* Morton LD; Sanecki RK; Gordon DE; Sopiarz RL; Bell JS; Sakas PS.
+ Juvenile renal disease in miniature schnauzer dogs.
Veterinary Pathology, 1990 Nov, 27(6):455-8.