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This article is from the Computer Viruses FAQ, by Nick FitzGerald n.fitzgerald@csc.canterbury.ac.nz with numerous contributions by others.

60 Can a DOS virus survive and spread on an OS/2 system using the HPFS file system?

Yes, both file-infecting and boot sector viruses can infect HPFS
partitions. File-infecting viruses function normally and can activate
and do their dirty deeds, and boot sector viruses can prevent OS/2 from
booting if the primary bootable partition is infected. Viruses that try
to address disk sectors directly cannot function under OS/2 because the
operating system prevents this activity.

 

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