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This article is from the Computer Viruses FAQ, by Nick FitzGerald n.fitzgerald@csc.canterbury.ac.nz with numerous contributions by others.

40 Is it possible to write-protect the hard disk with software only?

The answer is no. There are several programs that claim to do this, but
*all* of them can be bypassed with techniques already used by some
viruses. Therefore you should never rely on such programs *alone*,
although they can be useful in combination with other antivirus
measures.

 

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security, computer viruses, software, vendors, protection, infection, bomb, trojan, anti-virus, commercial, removal, false positive, BIOS, diagnostic