This article is from the WINE WINdows Emulator FAQ, by Dave Gardner firstname.lastname@example.org with numerous contributions by others.
Back when work on Wine was just getting started, it was said that any MS
Windows program that required a special enhanced mode device driver (VxD)
that couldn't be rewritten specifically for Wine, would not run under
Wine. While this is quite likely still a true statement for the most part,
there is preliminary VxD support being added to Wine at this time.