This article is from the MachTen & CodeBuilder FAQ, by Jaime Julca firstname.lastname@example.org with numerous contributions by others.
Because MachTen sits on top of the Macintosh file system and interoperates
with the Finder, all add-on hardware should work under MachTen. MachTen has
been used with Syquest drives, Bernoulli drives, Zip drives, accelerators,
multiport serial cards, ethernet cards (NuBus, SCSI, PCI) and video cards,
among others. In cases where MachTen takes control of the hardware (e.g., to
implement virtual memory), there could be incompatibilities.