Rofecoxib
(Vioxx, United States and Canada)

More drugs used for Pain.

Use:

Rofecoxib or Vioxx is used to reduce pain and inflammation.

How It Works:

Rofecoxib or Vioxx is a COX-2 specific inhibitor. Cyclo oxygenase compounds are found throughout the body - for example, in the nervous system and stomach. COX-2 is a type of cyclo oxygenase that produces prostaglandins that cause pain and inflammation. COX-1 is a type of cyclo oxygenase that is found in the stomach that helps protect the stomach lining. Thus, being specific for COX-2, Rofecoxib or Vioxx reduces pain and inflammation with little stomach irritation.

Side Effects:

Rofecoxib or Vioxx is generally well tolerated. It has a lower incidence of stomach side effects - irritation, ulcers, and even bleeding - than other anti inflammatory drugs.

Cautions for People:

People who have a sensitivity to other anti inflammatory drugs may be able to tolerate Rofecoxib or Vioxx, however they should use it with caution.

Drug Interactions:

While Rofecoxib or Vioxx does have a lower incidence of stomach adverse effects, care must be taken when combining it with other drugs, most notably other anti inflammatory drugs, because stomach irritation may result.

Further Reading:

Ann Pharmacother 1997;31:1335
NEJM 1997;337:141
Arthritis Rheum 1998;41:1591

Added to Virtual Drugstore January 1999.

The relevant product monographs must be regarded as the appropriate sources of prescribing information.

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