Epoetin Alfa (Eprex) Drug for Bloodless Surgery: Use, Side Effects, Interactions

Epoetin Alfa
(Eprex, United States and Canada)

Use:

Epoetin Alfa or Eprex is a recombinant form of erythropoietin which is a naturally produced in the kidney and stimulates red blood cell production.

How It Works:

Epoetin Alfa or Eprex mimics erythropoietin, a glycoprotein hormone which stimulated red blood cell production. It can be used intravenously prior to surgery to reduce blood loss.

Side Effects:

Epoetin Alfa or Eprex has been linked to seizures and thrombotic events.

Cautions for People:

People with uncontrolled hypertension cannot be exposed to Epoetin Alfa or Eprex. People who have seizure conditions such as epilepsy or who have blood coagulation problems must use Epoetin Alfa or Eprex with care. People with gout may be unable to use Epoetin Alfa or Eprex.

Drug Interactions:

Because Epoetin Alfa or Eprex promotes red blood cell production, a suitable iron and vitamin intake is required.

Further Reading:

Am J Med 1996;101(2A):4S
Am J Surg 1995;170(6A Suppl):60S
Drugs-Aging 1995;7(2):131

Added to Virtual Drugstore April 1997.

The relevant product monographs must be regarded as the appropriate sources of prescribing information.