Trovafloxacin (Trovan) Antibiotic Drug: Use, Side Effects, Interactions

Trovafloxacin
(Trovan, United States and Canada)

Use:

Trovafloxacin or Trovan is a quinolone antibiotic with a very broad spectrum of activity. It used to treat respiratory infections, abdominal infections, urinary tract infections, and prophylaxis before surgery.

How It Works:

Trovafloxacin or Trovan interferes with bacterial DNA, and thus bacterial ability to reproduce. It is active against gram positive and gram negative bacteria as well as atypical and anaerobic bacteria.

Side Effects:

Trovafloxacin or Trovan is generally well tolerated, however dizziness, headache, and nausea have been reported. To reduce these side effects it is recommended to take it at bedtime or with food.

Cautions for People:

Trovafloxacin or Trovan is a quinolone antibiotic and these antibiotics seem to be involved in joint problems, specifically tendinitis, thus people at increased risk for this type of problem should be closely monitored.
Trovafloxacin or Trovan has been associated with reports of liver toxicity and pancreatitis. People taking the drug should be aware of symptoms of these conditions such as nausea, abdominal pain, jaundice, fatigue.
Pregnant women and lactating mothers should use Trovafloxacin or Trovan with care.
Becuase of the risk for severe liver toxicity, Trovafloxacin or Trovan's use is limited to people with potentially life-threatening infections who are being treated in hospitals or long-term care facilities.

Drug Interactions:

Antacids or highly buffered drugs can reduce Trovafloxacin or Trovan's absorption. In fact taking Trovafloxacin or Trovan with an acidic beverage such as a cola drink may increase its absorption.

Further Reading:

Medical Letter 1998;40(1022):30

Added to Virtual Drugstore May 1999.
Revised September 1999.

The relevant product monographs must be regarded as the appropriate sources of prescribing information.