Description
This article is from the Interpretation Of
Lab Test Profiles, by Ed Uthman uthman@neosoft.com with
numerous contributions by others.
11 CREATININE
Increase in serum creatinine is seen any renal functional
impairment. Because of its insensitivity in detecting early
renal failure, the creatinine clearance is significantly reduced
before any rise in serum creatinine occurs. The renal impairment
may be due to intrinsic renal lesions, decreased perfusion of
the kidney, or obstruction of the lower urinary tract.
Nephrotoxic drugs and other chemicals include:
antimony arsenic bismuth cadmium
copper gold iron lead
lithium mercury silver thallium
uranium aminopyrine ibuprofen indomethacin
naproxen fenoprofen phenylbutazone phenacetin
salicylates aminoglycosides amphotericin cephalothin
colistin cotrimoxazole erythromycin ampicillin
methicillin oxacillin polymixin B rifampin
sulfonamides tetracyclines vancomycin benzene
zoxazolamine tetrachloroethylene ethylene glycol
acetazolamide aminocaproic acid aminosalicylate boric acid
cyclophosphamide cisplatin dextran (LMW) furosemide
mannitol methoxyflurane mithramycin penicillamine
pentamide phenindione quinine thiazides
carbon tetrachloride
Deranged metabolic processes may cause increases in serum
creatinine, as in acromegaly and hyperthyroidism, but dietary
protein intake does not influence the serum level (as opposed to
the situation with BUN). Some substances interfere with the
colorimetric system used to measure creatinine, including
acetoacetate, ascorbic acid, levodopa, methyldopa, glucose and
fructose. Decrease in serum creatinine is seen in pregnancy and
in conditions characterized by muscle wasting.
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