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This article is from the Chronic Fatigue Syndrome (CFS) FAQ, by cfs-news@cais.com (Roger Burns) with numerous contributions by others.
Enough is known about the mechanisms of both diseases to say that they
are not the same. The fact that they both seem to involve the immune
system, and that some not-fully-researched viruses might have some
effect in both, have caused a few people (notably Neenyah Ostrom, a
writer for the New York Native) to speculate that there is a common
mechanism. The facts that CFS has no correlation to HIV nor shows any
AIDS-like breakdown of the immune system shows that these illnesses
are not the same. It is nonetheless true that the broad family of
immune-related illnesses are becoming increasingly important in these
times.
 
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